產品詳情
簡單介紹:
JumonjiHDMInhibitor,JIB-04
詳情介紹:
Purpose | A potent jumonji HDM inhibitor |
Characteristics | JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC?? values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate , it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models. |
Purity | ≥ 98?% by HPLC |
Chemical Name | 5-Chloro-2-[(E)-2-[phenyl(pyridin-2?-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627 |
Formula | C??H??ClN? |
Permeability | Cell-permeable |
Solubility | DMSO (approx. 20 mg/mL) |
Molecular Weight | 308.76 g/mol |
CAS-No | 199596-05-9 |
Comment |
JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of -ketoglutarate , it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models |
Restrictions | For Research Use only |
Format | Solid |
Handling Advice | Protect from air and light |
Storage | -20 °C |
Expiry Date | 24 months |
Supplier Images |
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